4-HYDROXY-2-QUINOLONES. 179. SYNTHESIS, STRUCTURE, AND ANTI-INFLAMMATORY ACTIVITY OF 4-HYDROXY-1-METHYL-2-OXO-1,2-DIHYDROQUINOLIN-3-YLACETIC ACID AND ITS DERIVATIVES

Authors

  • И. В. Украинец National University of Pharmacy, Kharkiv 61002
  • Е. В. Моспанова Chemical Technology Institute, V. Dal East-Ukrainian National University, Rubizhne 93003
  • А. А. Давиденко N. I. Pirogov Vinnitsa National Medical University, Vinnitsa 21018
  • А. А. Ткач National University of Pharmacy, Kharkiv 61002
  • О. В. Горохова National University of Pharmacy, Kharkiv 61002

DOI:

https://doi.org/10.1007/4915

Keywords:

4-hydroxy-2-oxo-1, 2-dihydroquinolin-3-ylacetic acids, amidation, anti-inflammatory activity, X-ray analysis, esterification

Abstract

The synthesis of 4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinolin-3-ylacetic acid has been carried out and the structure and acid properties studied. Preparative methods for its esterification and amidation are proposed. The anti-inflammatory properties of the synthesized compounds have been evaluated.

How to Cite
Ukrainets, I. V.; Mospanova, E. V.; Davidenko, A. A.; Tkach, A. A.; Gorokhova, O. V. Chem. Heterocycl. Compd. 2010, 46, 947. [Khim. Geterotsikl. Soedin. 2010, 1173.]

For this article in the English edition see DOI 10.1007/s10593-010-0607-x

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Published

2019-01-15

Issue

No. 8 (2010)

Section

Original Papers