SODIUM HYPOCHLORITE-MEDIATED SYNTHESIS OF 2,5-DISUBSTITUTED 1,3,4-OXADIAZOLES FROM HYDRAZIDES AND ALDEHYDES

Authors

  • Karuna Raman Paidi Sri Krishnadevaraya University, Ananthapur, Andhra Pradesh 515003, India
  • Murali Krishna Kolli Sri Krishnadevaraya University, Ananthapur, Andhra Pradesh 515003, India
  • Eeda Koti Reddy Vignan's Foundation for Science, Technology and Research (Deemed to be University), Guntur–Tenali Rd., Vadlamudi, Andhra Pradesh 522213, India
  • Venkata Ramana Pedakotla Sri Krishnadevaraya University, Ananthapur, Andhra Pradesh 515003, India

DOI:

https://doi.org/10.1007/5332

Keywords:

N-acylhydrazone, aldehyde, hydrazide, oxadiazole, sodium hypochlorite, oxidative cyclization.

Abstract

A simple and convenient method for the synthesis of 2,5-disubstituted 1,3,4-oxadiazoles has been developed. Structurally divergent symmetrical and unsymmetrical 2,5-disubstituted 1,3,4-oxadiazoles can be obtained in moderate to high yields via NaOCl-mediated oxidative cyclization of N-acylhydrazones, generated in situ from aliphatic and aromatic hydrazides and aldehydes.

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Published

2020-04-01

Issue

Vol. 56 No. 3 (2020)

Section

Original Papers