SYNTHESIS OF BENZO[<i>c</i>][1,7]NAPHTHYRIDINE DERIVATIVES

Authors

  • Антон Л. Шацаускас Omsk State Technical University, 11 Mira Ave., Omsk 644050, Russia;
  • Элина Р. Сайбулина Dostoevsky Omsk State University, 55a Mira Ave., Omsk 644077, Russia
  • Юрий В. Гатилов N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, 9 Akademika Lavrentieva Ave., Novosibirsk 630090, Russia Novosibirsk State University, 2 Pirogova St., Novosibirsk 630090, Russia
  • Анастасия С. Костюченко Omsk State Technical University, 11 Mira Ave., Omsk 644050, Russia; Dostoevsky Omsk State University, 55a Mira Ave., Omsk 644077, Russia
  • Александр С. Фисюк Omsk State Technical University, 11 Mira Ave., Omsk 644050, Russia;

DOI:

https://doi.org/10.1007/5363

Keywords:

benzo[c][1, 7]naphthyridine, alkylation, electrophilic substitution, nucleophilic substitution, oxidation, reactivity.

Abstract

Reactivity of 2-methyl-6-phenylbenzo[c][1,7]naphthyridine in alkylation, oxidation, and electrophilic substitution reactions has been studied. The reaction of 2-methyl-6-phenylbenzo[c][1,7]naphthyridines with POCl3 yielded the previously unknown 4-chloro-2-methyl-6-phenylbenzo[c]-[1,7]naphthyridine. Its dehalogenation and substitution of halogen by nitrogen and sulfur nucleophiles were studied.

Published

2019-11-12

Issue

Section

Original Papers