ECO-FRIENDLY AND SUSTAINABLE SYNTHETIC APPROACHES TO BIOLOGICALLY SIGNIFICANT FUSED N-HETEROCYCLES

Authors

  • Shiv Shankar Gupta Natural Product Chemistry and Process Development Division and AcSIR, CSIR-Institute of Himalayan Bioresource Technology, Palampur, Himachal Pradesh, 176061, India
  • Surekha Kumari Natural Product Chemistry and Process Development Division and AcSIR, CSIR-Institute of Himalayan Bioresource Technology, Palampur, Himachal Pradesh, 176061, India
  • Inder Kumar Natural Product Chemistry and Process Development Division and AcSIR, CSIR-Institute of Himalayan Bioresource Technology, Palampur, Himachal Pradesh, 176061, India
  • Upendra Sharma Natural Product Chemistry and Process Development Division and AcSIR, CSIR-Institute of Himalayan Bioresource Technology, Palampur, Himachal Pradesh, 176061, India

DOI:

https://doi.org/10.1007/5489

Keywords:

drug molecules, fused heterocycles, metal-free approach, multicomponent reactions.

Abstract

This review summarizes environmentally benign approaches for the synthesis of fused N-heterocycles since 2011. It is mainly focused on one-pot, multicomponent protocols for generating fused N-heterocyclic moieties with biological significance in atom-efficient manner. Several attractive and cost-effective approaches such as metal-, catalyst-, and solvent-free methods are discussed in this review. Electrochemical concept as green and environmentally optional strategy to produce fused N-heterocycles is also discussed. Synthesis of natural bioactive compounds like clausine V, glycoborine, and popular commercial drug alprazolam (Xanax) by utilizing such strategy is described.

Author Biographies

Shiv Shankar Gupta, Natural Product Chemistry and Process Development Division and AcSIR, CSIR-Institute of Himalayan Bioresource Technology, Palampur, Himachal Pradesh, 176061, India

NPC&PDD, CSIR-IHBT, Palampur, India

Surekha Kumari, Natural Product Chemistry and Process Development Division and AcSIR, CSIR-Institute of Himalayan Bioresource Technology, Palampur, Himachal Pradesh, 176061, India

CSIR-IHBT, Palampur, India

Inder Kumar, Natural Product Chemistry and Process Development Division and AcSIR, CSIR-Institute of Himalayan Bioresource Technology, Palampur, Himachal Pradesh, 176061, India

CSIR-IHBT, Palampur, India

Upendra Sharma, Natural Product Chemistry and Process Development Division and AcSIR, CSIR-Institute of Himalayan Bioresource Technology, Palampur, Himachal Pradesh, 176061, India

Scientist, CSIR-IHBT, Palampur, India 176061

Downloads

Published

2020-04-30

Issue

Vol. 56 No. 4 (2020): Green chemistry of heterocycles

Section

Review Articles