SYNTHESIS AND STRUCTURE OF 2-ARYLAMINO-SUBSTITUTED 4-(DICHLOROMETHYLIDENE)-3-NITRO-4<i>H</i>-PYRIDO[1,2-<i>a</i>]PYRIMIDINES

Authors

  • Ирина А. Колесник Institute of Physical Organic Chemistry, National Academy of Sciences of Belarus, 13 Surganova St., Minsk 220072, Belarus
  • Сергей К. Петкевич Institute of Physical Organic Chemistry, National Academy of Sciences of Belarus, 13 Surganova St., Minsk 220072, Belarus
  • Петр В. Курман Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, 5/2 Akademika V. F. Kuprevicha St., Minsk 220141, Belarus
  • Александр С. Ляхов Scientific Research Institute for Physical Chemical Problems, Belarusian State University, 14 Leningradskaya St., Minsk 220006, Belarus
  • Людмила С. Ивашкевич Scientific Research Institute for Physical Chemical Problems, Belarusian State University, 14 Leningradskaya St., Minsk 220006, Belarus
  • Хонгвэй Чжоу College of Biological, Chemical Sciences and Engineering, Jiaxing University, Jiaxing, Zhejiang 314001, China
  • Владимир И. Поткин Institute of Physical Organic Chemistry, National Academy of Sciences of Belarus, 13 Surganova St., Minsk 220072, Belarus

DOI:

https://doi.org/10.1007/5795

Keywords:

arylamine, azole, nitrobutadiene, pyrido[1, 2-a]pyrimidine, heterocyclization, nucleophilic substitution

Abstract

The reaction of 4-substituted anilines with 3,4,4-trichloro-1,1-bis(3,5-dimethyl-1H-pyrazol-1-yl)-2-nitrobuta-1,3-dienes led to 1-arylamino-3,4,4-trichloro-1-(3,5-dimethyl-1H-pyrazol-1-yl)-2-nitrobuta-1,3-dienes, which under the action of 2-aminopyridines underwent heterocyclization to the corresponding 2-arylamino-substituted 4-(dichloromethylidene)-3-nitro-4H-pyrido[1,2-a]pyrimidines. The molecular structure of 4H-pyrido[1,2-a]pyrimidine containing the (4-ethoxyphenyl)amine substituent at position 2 was determined by X-ray structural analysis.

Author Biographies

Ирина А. Колесник, Institute of Physical Organic Chemistry, National Academy of Sciences of Belarus, 13 Surganova St., Minsk 220072, Belarus

Junior reseacher in the Laboratory of organoelement compounds

Сергей К. Петкевич, Institute of Physical Organic Chemistry, National Academy of Sciences of Belarus, 13 Surganova St., Minsk 220072, Belarus

Leading reseacher in the Laboratory of organoelement compounds

Петр В. Курман, Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, 5/2 Akademika V. F. Kuprevicha St., Minsk 220141, Belarus

Leading reseacher in the Laboratory of physicochemical methods of research

Александр С. Ляхов, Scientific Research Institute for Physical Chemical Problems, Belarusian State University, 14 Leningradskaya St., Minsk 220006, Belarus

Leading reseacher in the Laboratory for chemistry of condenced systems

Людмила С. Ивашкевич, Scientific Research Institute for Physical Chemical Problems, Belarusian State University, 14 Leningradskaya St., Minsk 220006, Belarus

Head of the Laboratory of physicochemical investigations

Хонгвэй Чжоу, College of Biological, Chemical Sciences and Engineering, Jiaxing University, Jiaxing, Zhejiang 314001, China

Head of the College of biological, chemical sciences and engineering

Владимир И. Поткин, Institute of Physical Organic Chemistry, National Academy of Sciences of Belarus, 13 Surganova St., Minsk 220072, Belarus

Head of the Organic chemistry department

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Published

2020-10-14

Issue

Vol. 56 No. 9 (2020)

Section

Original Papers