QUADRUPLE BOND FORMING MULTICOMPONENT APPROACH TO 5-(3-CHROMENYL)-5<i>H</i>-CHROMENO[2,3-<i>b</i>]PYRIDINES AND ITS INTERACTION WITH THE NEUROPEPTIDE Y1 RECEPTOR

Abstract

Multicomponent reactions employ three or more reactants to obtain heterocycles containing fragments of all starting materials in a onepot
process. All new bonds are formed at once, hence multicomponent reactions are characterized by high bond-forming index. A new multicomponent, one-pot reaction yielding previously unknown 5-(4-hydroxy-2-oxo-2H-chromen-3-yl)-5H-chromeno[2,3-b]pyridines in 52–94% yield has been found. This multicomponent approach allows to construct four new bonds to synthesize some 5H-chromeno[2,3-b]pyridines under mild conditions. Molecular docking and dynamics studies of the synthesized structures were carried out to identify their interaction with the binding pocket of the neuropeptide Y1 receptor.