SYNTHESIS AND ANTIHERPETIC ACTIVITY OF NOVEL PURINE CONJUGATES WITH 7,8-DIFLUORO-3-METHYL-3,4-DIHYDRO-2<i>H</i>-1,4-BENZOXAZINE

Authors

  • Ольга А. Воздвиженская Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 22/20 Sofyi Kovalevskoi St., Yekaterinburg 620108, Russia
  • Валерия Л. Андронова D. I. Ivanovsky Institute of Virology, Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation, 16 Gamaleya St., Moscow 123098, Russia
  • Георгий А. Галегов D. I. Ivanovsky Institute of Virology, Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation, 16 Gamaleya St., Moscow 123098, Russia
  • Галина Л. Левит Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 22/20 Sofyi Kovalevskoi St., Yekaterinburg 620108, Russia
  • Виктор П. Краснов Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 22/20 Sofyi Kovalevskoi St., Yekaterinburg 620108, Russia Institute of Chemical Engineering, Ural Federal University, 19 Mira St., Yekaterinburg 620062, Russia
  • Валерий Н. Чарушин Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 22/20 Sofyi Kovalevskoi St., Yekaterinburg 620108, Russia Institute of Chemical Engineering, Ural Federal University, 19 Mira St., Yekaterinburg 620062, Russia

DOI:

https://doi.org/10.1007/6033

Keywords:

ω-amino acids, 6-chloropurine, 7, 8-difluoro-3-methyl-3, 4-dihydro-2H-1, 4-benzoxazine, antiviral activity, herpes simplex virus type 1.

Abstract

A method for the synthesis of novel purine conjugates with 7,8-difluoro-3-methyl-3,4-dihydro-2H-1,4-benzoxazine containing fragments of ω-amino acids with different lengths of the polymethylene chain as a linker has been developed. It was found in experiments in vitro that the obtained compounds are active against the herpes simplex virus type 1, including the acyclovir-resistant strain.

Author Biographies

Ольга А. Воздвиженская, Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 22/20 Sofyi Kovalevskoi St., Yekaterinburg 620108, Russia

младший научный сотрудник

Валерия Л. Андронова, D. I. Ivanovsky Institute of Virology, Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation, 16 Gamaleya St., Moscow 123098, Russia

кандидат биологических наук, ведущий научный сотрудник

Георгий А. Галегов, D. I. Ivanovsky Institute of Virology, Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation, 16 Gamaleya St., Moscow 123098, Russia

Руководитель лаборатории химиотерапии вирусных инфекций, д.б.н., профессор

Галина Л. Левит, Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 22/20 Sofyi Kovalevskoi St., Yekaterinburg 620108, Russia

д.х.н., ведущий научный сотрудник

Виктор П. Краснов, Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 22/20 Sofyi Kovalevskoi St., Yekaterinburg 620108, Russia Institute of Chemical Engineering, Ural Federal University, 19 Mira St., Yekaterinburg 620062, Russia

Заведующий лабораторией асимметрического синтеза

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Published

2021-05-05

Issue

Vol. 57 No. 4 (2021): Heterocycles Against Viruses

Section

Original Papers