FREE-RADICAL AND ELECTROPHILIC FUNCTIONALIZATION OF PYRAZOL-3-ONES WITH C–O OR C–N BOND FORMATION

Authors

  • Elena R. Lopat'eva N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Ave., Moscow 119991, Russia Mendeleev University of Chemical Technology of Russia, 9 Miusskaya Sq., Moscow 125047, Russia
  • Igor B. Krylov N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Ave., Moscow 119991, Russia Mendeleev University of Chemical Technology of Russia, 9 Miusskaya Sq., Moscow 125047, Russia

DOI:

https://doi.org/10.1007/6064

Keywords:

Pyrazolones, pyrazol-3-ones, free redicals, C-O coupling, C-N coupling

Abstract

Pyrazol-3-ones are known as a class of anti-inflammatory drugs and popular
heterocycles in search for new bioactive substances. The electrophilic or free-radical functionalization of C-4 position of pyrazolin-3-ones with the formation of C–C, C–S, C–Hal, C–N, and C–O bonds has been extensively developed in the last decade. Among these methods, the C–O or C–N bond forming reactions are studied less. This microreview covers selected examples of such reactions published in the last 10 years.

Author Biography

Igor B. Krylov, N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Ave., Moscow 119991, Russia Mendeleev University of Chemical Technology of Russia, 9 Miusskaya Sq., Moscow 125047, Russia

Laboratory for Studies of Homolytic Reactions, PhD, Senior Researcher

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Published

2021-02-22

Issue

Vol. 57 No. 2 (2021)

Section

Heterocycles in Focus