PREPARATION OF AMINOTRIAZOLETHIONE DERIVATIVES FROM N-ARYL-N-CARBOXYETHYL-β-ALANINES

Abstract

Depending on the substituents in the aryl moiety, the fusion of N-aryl-N-ethoxycarbonyl-β-alanines with thiocarbohydrazide gives di- or monotriazole derivatives, namely, 4-amino-(2-{[2-(4-amino-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)ethyl]anilino}ethyl)-4,5-dihydro-1H-1,2,4-triazole-5-thiones, 1-[2-(4-amino-
5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)ethyl]-2,3-dihydroquinolin-4(1H)-ones, 4-amino-3-[2-(4-methylanilino))ethyl]-4,5-dihydro-1H-1,2,4-triazole-5-thione and 4-amino-3-[2-(4-ethoxyanilino)ethyl]-4,5-dihydro-1H-1,2,4-triazole-5-thione. A ditriazolethione derivative was also obtained from the diethyl ester of N-ethoxycarbonyl-N-(4-ethoxyphenyl)-β-alanine.

How to Cite
Tumosienė, I.; Beresnevičius, Z. J. Chem. Heterocycl. Compd. 2009, 45, 1257. [Khim. Geterotsikl. Soedin. 2009, 1564.]

For this article in the English edition see DOI 10.1007/s10593-010-0416-2