PREPARATION OF N-PHENYL-SUBSTITUTED QUINOLINIUM DERIVATIVES LABELED WITH TRITIUM BY CHEMONUCLEAR SYNTHESIS

Authors

  • Н. Е. Щепина Natural Sciences Institute, Perm State University, Perm 614990
  • В. В. Аврорин Saint Petersburg State University, Saint Petersburg 199034
  • Г. А. Бадун M. V. Lomonosov Moscow State University, Moscow 119991
  • Г. А. Александрова Natural Sciences Institute, Perm State University, Perm 614990
  • С. Е. Уханов Perm State Technical University, Perm 614600
  • В. М. Федосеев M. V. Lomonosov Moscow State University, Moscow 119991
  • С. Б. Льюис James Madison University, Harrisonburg, VA
  • И. И. Бойко "Tekhnolog", Pereslavl-Zalessky 152025, Yaroslavl region

DOI:

https://doi.org/10.1007/6638

Keywords:

N-phenylquinolinium and quinaldinium salts, tritium, phenyl cations, six-membered nitrogen heterocyclic compounds, chemonuclear synthesis

Abstract

A chemonuclear method of synthesis is proposed for obtaining difficultly available phenyl-substituted derivatives of quinoline labeled with tritium. The ion-molecule reaction of free phenyl cations, generated on β-decay of tritium, with the nucleophilic centers of heterocyclic compounds is the basis of the synthesis. The onium derivatives synthesized possess significant inhibitory antimicrobial activity and are promising for a detailed study of the  reaction mechanisms and metabolic processes using radioactive indicators.

How to Cite
Shchepina, N. E.;Avrorin, V. V.; Badun, G. A.; Alexandrova, G. A.; Ukhanov, S. E.; Fedoseev, V. M.; Lewis, S. B.; Boiko, I. I. Chem. Heterocycl. Compd. 2009, 45, 796. [Khim. Geterotsikl. Soedin. 2009, 1008.]

For this article in the English edition see DOI 10.1007/s10593-009-0359-7


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Published

2022-02-28

Issue

No. 7 (2009)

Section

Original Papers