QUINAZOLINES. 1. SYNTHESIS AND CHEMICAL REACTIONS OF 6-CHLOROSULFONYLQUINAZOLINE-2,4-DIONES

Authors

  • Р. Ш. Курязов S. Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences Republic of Uzbekistan, Tashkent 700170
  • Н. С. Мухамедов S. Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences Republic of Uzbekistan, Tashkent 700170
  • Х. М. Шахидоятов S. Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences Republic of Uzbekistan, Tashkent 700170

DOI:

https://doi.org/10.1007/7006

Keywords:

2, 4-dioxoquinazoline-6-sulfonic acid amides, 4-dioxoquinazoline-6-sulfonic acids, symmetrical 1, 3-dialkylquinazoline-2, 4-diones, 6-chlorosulfonylquinazoline-2, nucleophilic and electrophilic substitution

Abstract

Treatment of quinazoline-2,4-dione and its symmetrical 1,3-dialkyl derivatives with chlorosulfonic acid gave the corresponding 6-chlorosulfonylquinazoline-2,4-diones. Reaction of the compounds obtained with nucleophilic agents (water, ammonia, aliphatic and cyclic amines) gave the corresponding free 2,4-dioxoquinazoline-6-sulfonic acids, 6-sulfamidoquinazoline-2,4-diones, and 2,4-dioxoquinazoline-6-sulfonic acid amides.

How to Cite
Kuryazov, R. Sh.; Mukhamedov, N. S.; Shakhidoyatov, Kh. M.  Chem. Heterocycl. Compd. 2008, 44, 324. [Khim. Geterotsikl. Soedin. 2008, 420.]

For this article in the English edition see DOI 10.1007/s10593-008-0048-y


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Published

2022-08-22

Issue

No. 3 (2008)

Section

Original Papers