INVESTIGATION OF THE CONFORMATIONAL TRANSFORMATIONS IN SOME 7α-METHYL-6-OXA-14β-ANALOGS OF STEROIDAL ESTROGENS BY NMR SPECTROSCOPY

Authors

  • C. И. Селиванов St. Petersburg State University, Chemical Faculty, St. Petersburg 198504
  • С. Н. Морозкина St. Petersburg State University, Chemical Faculty, St. Petersburg 198504
  • А. С. Ченцова St. Petersburg State University, Chemical Faculty, St. Petersburg 198504
  • А. Г. Шавва St. Petersburg State University, Chemical Faculty, St. Petersburg 198504

DOI:

https://doi.org/10.1007/7085

Keywords:

6-oxa-14β-analogs of steroidal estrogens, conformational equilibria, NMR spectroscopy

Abstract

The stereochemical structure and conformational transformations of two 6-oxa-14β-estra-1,3,5(10),8(9)-tetraenes having an α-methyl group at position 7 were investigated. It was found that the substituent at the C-17 atom has an effect on the formation of the conformers in solution. In the analog containing a C-17 keto group in solution there are two conformers, whereas the 17α-acetoxy derivative has only one conformer.

How to Cite
Selivanov, S. I.; Morozkina, S. N.; Chentsova, A. S.; Shavva, A. G.  Chem. Heterocycl. Compd. 2008, 44, 654. [Khim. Geterotsikl. Soedin. 2008, 821.]

For this article in the English edition see DOI 10.1007/s10593-008-0091-8

 

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Published

2022-09-28

Issue

No. 6 (2008)

Section

Original Papers