KINETIC RESOLUTION OF N-METHYL-2-PHENYLPYRROLIDINE BY CYCLOPALLADATION IN THE PRESENCE OF AN OPTICALLY ACTIVE BASE

Abstract

The possibility of the kinetic resolution of the racemic C*-chiral ligand in the course of its ortho-palladation in the presence of an optically active base was shown for the first time using a tertiary heterocyclic amine as the ligand. The absolute configuration of the C*-stereocenter in the predominant enantiomer of the dimeric complex was established by the X-ray diffraction of (S)-prolinate derivative.

Authors: V. V. Dunina, L. G. Kuz'mina, E. D. Razmyslova, and V. P. Kislyi.

English Translation in Chemistry of Heterocyclic Compounds, 1999, 35 (8), pp 1001-1011

http://link.springer.com/article/10.1007/BF02252170