ANNELATION OF 3,4-DIHYDROISOQUINOLINES BY 3-ACYL-5,5-DIMETHYLTHIOPYRAN-2,4-DIONES. SYNTHESIS AND PROPERTIES OF 8-AZA-17-THIA-<i>D</i>-HOMOGONA-12,17a-DIONES

Authors

  • M. V. Budnikova Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, Minsk 220141
  • O. V. Gulyakevich Institute of Bioorganic Chemistry, National Academy of Sciences of the Republic of Belarus, Minsk 220141
  • T. A. Zheldakova Institute of Bioorganic Chemistry, National Academy of Sciences of the Republic of Belarus, Minsk 220141
  • A. L. Mikhal'chuk Institute of Bioorganic Chemistry, National Academy of Sciences of the Republic of Belarus, Minsk 220141
  • D. B. Rubinov Institute of Bioorganic Chemistry, National Academy of Sciences of the Republic of Belarus, Minsk 220141

DOI:

https://doi.org/10.1007/s10593-005-0019-5

Keywords:

8-aza-17-thia-D-homogonanes, azomethines, 3-acyl-5,5-dimethyltetrahydrothiopyran-2,4-diones, heterosteroids, 3,4-dihydroisoquinolines, Schiff's bases, thiopyrano[3',4':5,6]pyrido[2,1-a]isoquinolines, annelation, [2+4] cyclocondensation

Abstract

We have used annelation of 3,4-dihydroisoquinolines by 3-acyl-5,5-dimethylthiopyran-2,4-diones to obtain the corresponding 8-aza-17-thia-D-homogonanes, which are novel representatives of heterosteroids. We have studied the tautomerism of 3-acylthiopyran-2,4-diones using NMR spectroscopy and H/D-isotope exchange. We have obtained 2H-isotopomers of 3-acylthiopyran-2,4-
diones.

How to Cite
Budnikova, M. V.; Gulyakevich, O. V.; Zheldakova, T. A.; Mikhal'chuk, A. L.; Rubinov, D. B. Chem. Heterocycl. Compd. 2004, 40, 1359. [Khim. Geterotsikl. Soedin. 2004, 1572.]

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Published

2004-10-25

Issue

No. 10 (2004)

Section

Original Papers