INTERACTION OF CYCLIC SCHIFF'S BASES WITH 2-METHYLTHIOPYRIMIDINE-4,6-DIONE ENOL ACETATE. SYNTHESIS OF 5-(2-ACETYL-6,7-DIMETHOXY-1,2,3,4-TETRAHYDRO-1-ISOQUINOLYL)-6-HYDROXY-2-METHYLTHIO-1,4-DIHYDRO-4-PYRIMIDINONES

Authors

  • O. V. Gulyakevich Institute of Bioorganic Chemistry, National Academy of Sciences of the Republic of Belarus, Minsk 220141
  • K. A. Krasnov Saint-Petersburg I. I. Mechnikov State Medical Academy, Saint-Petersburg 195067
  • A. L. Mikhal'chuk Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, Minsk 220141
  • A. A. Akhrem Institute of Bioorganic Chemistry, National Academy of Sciences of the Republic of Belarus, Minsk 220141

Keywords:

3,4-dihydroisoquinolines, pyrimidine-4,6-dione enol acetates, 5-(1-isoquinolyl)pyrimidines, condensation reaction

Abstract

5-(2-Acetyl-1,2,3,4-tetrahydro-1-isoquinolyl)-6-hydroxy-2-methylthio-1,4-dihydro-4-pyrimidinones have been obtained by the interaction of 3,4-dihydroisoquinolines with 2-methylthio-4-oxo-1,4-dihydro-6-pyrimidinyl acetate. It was shown that N,O-methyl derivatives are formed in interaction of the obtained products with diazomethane.

How to Cite
Gulyakevich, O. V.; Krasnov, K. A.; Mikhal'chuk, A. L.; Akhrem, A. A. Chem. Heterocycl. Compd. 2004, 40, 1070. [Khim. Geterotsikl. Soedin. 2004, 1233.]

For this article in the English edition, see DOI 10.1023/B:COHC.0000046699.57251.f4

Downloads

Published

2004-08-25

Issue

No. 8 (2004)

Section

Original Papers