SYNTHESIS OF 2-ARYLQUINAZOLINES BY CHAN–EVANS–LAM COUPLING OF 2-FORMYLPHENYLBORONIC ACIDS WITH AMIDINES

Authors

  • Vitalii V. Solomin Latvian Institute of Organic Synthesis, 21 Aizkraukles St., Riga LV-1006, Latvia; Riga Technical University, Faculty of Materials Science and Applied Chemistry, 3/7 Paula Valdena St., Riga LV-1048, Latvia https://orcid.org/0000-0002-2117-8356
  • Darija Zaharova Latvian Institute of Organic Synthesis, 21 Aizkraukles St., Riga LV-1006, Latvia
  • Aigars Jirgensons Latvian Institute of Organic Synthesis, 21 Aizkraukles St., Riga LV-1006, Latvia https://orcid.org/0000-0002-8937-8792

Keywords:

amidines, arylquinazolines, Chan–Evans–Lam coupling, Copper catalysis, azaheterocyclization

Abstract

A method for the synthesis of 2-arylquinazolines is described which involves Chan–Evans–Lam coupling of 2-formylphenylboronic
acids with amidines. The reaction is performed at mild conditions compatible with the range of functional groups and is cost-efficient,
provided by usage of inexpensive catalyst and reagents. The synthesis method of 2-arylquinazolines presented is of with scope in both
2-formylphenylboronic acids and amidines.

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Published

2024-05-28

Issue

Vol. 60 No. 3/4 (2024)

Section

Original Papers