4-HYDROXY-2-QUINOLONES. 56. 4-(ADAMANT-1-YL)THIAZOLYL-2-AMIDES OF 1-R-4-HYDROXY-2-OXOQUINOLINE-3-CARBOXYLIC ACIDS AS POTENTIAL ANTITUBERCULAR AGENTS

Authors

  • И. B. Украинец Ukrainian National Pharmaceutical Academy, Kharkov 6100
  • М. Амер Ukrainian National Pharmaceutical Academy, Kharkov 61002
  • П. А. Безуглый Ukrainian National Pharmaceutical Academy, Kharkov 61002
  • O. B. Горохова Ukrainian National Pharmaceutical Academy, Kharkov 61002
  • Л. B. Сидоренко Ukrainian National Pharmaceutical Academy, Kharkov 61002
  • А. B. Туров Taras Shevchenko National University, Kiev 01030

Keywords:

adamantane, 4-hydroxy-2-quinolone, thiazole, antitubercular activity

Abstract

The synthesis, antitubercular, anti-HIV, and antitumor activity of the 4-(adamant-1-yl)thiazolyl-2-amides of 1-R-4-

hydroxy-2-oxoquinoline-3-carboxylic acids have been studied. An efficient method for purifying the 4-hydroxy-2-oxoquinoline derivatives from their metal salts is proposed.

How to Cite
Ukrainets, I. V.; Amer, M.; Bezuglyi, P. A.; Gorokhova, O. V.; Sidorenko, L. V.; Turov, A. V Chem. Heterocycl. Compd. 2002, 38, 571. [Khim. Geterotsikl. Soedin. 2002, 654.]

For this article in the English edition, see DOI https://doi.org/10.1023/A:1019513313773

 

 

Downloads

Published

2002-05-25

Issue

No. 5 (2002)

Section

Original Papers