SYNTHESIS OF 4-(1-ADAMANTYL)- AND 4-(1-ADAMANTYLMETHYL)-SUBSTITUTED HALOTHIAZOLES

Authors

  • H. B. Макарова Samara State Technical University, Samara
  • M. H. Земцова Samara State Technical University, Samara
  • И. K. Моисеев Samara State Technical University, Samara

Keywords:

adamantyl- and adamantylmethyl-substituted halothiazoles, dibromo ketones, thioureas, thiocyanatoketones, cyclization

Abstract

1-Adamantyl bromomethyl ketone and 1-adamantylmethyl chloromethyl ketone react with potassium thiocyanate in dimethylformamide to give the corresponding thiocyanatoketones which cyclize under the influence of HCl into 4-(1-adamantyl) and 4(-adamantylmethyl)chlorothiazole respectively. 4‑(1‑Adamantyl)-2-amino-5-bromothiazole and its N-derivative were synthesized by the reaction of 1‑adamantyl dibromomethyl ketone with thioureas and N-substituted thiourea in acetonitrile.

How to Cite
Makarova, N. V.; Zemtsova, M. N.; Moiseev, I. K..  Chem. Heterocycl. Compd. 2001, 37, 1266. [Khim. Geterotsikl. Soedin. 2001, 1384.]

For this article in the English edition, see DOI https://doi.org/10.1023/A:1013809913189

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Published

2001-10-25

Issue

No. 10 (2001)

Section

Original Papers