ALKYLATION OF TETRAHYDROPYRIMIDINE-2-THIONES WITH ETHYL CHLOROACETATE

Authors

  • А. К. Ширяев Samara State Technical University
  • Н. Г. Колесникова Samara State Technical University
  • Н. М. Кузнецова Samara State Technical University
  • Е. А. Лашманова Samara State Technical University

DOI:

https://doi.org/10.1007/973

Keywords:

dihydropyrimidines, esters of haloacetic acids, tetrahydropyrimidine-2-thiones, thiazolo[3, 2-a]pyrimidines, alkylation, hydrolysis

Abstract

Reaction conditions were found for the alkylation of tetrahydropyrimidine-2-thiones with ethyl chloroacetate, preventing a subsequent cyclization. Only one of the ester groups in the obtained alkylation products was subject to alkaline hydrolysis, while a treatment with ammonia in alcohol resulted in thiazolo[3,2‑a]pyrimidines.

How to Cite
Shiryaev, A. K.; Kolesnikova, N. G.; Kuznetsova, N. M.; Lashmanova, E. A. Chem. Heterocycl. Compd. 2014, 49, 1681. [Khim. Geterotsikl. Soedin. 2013, 1812.]

For this article in the English edition see DOI 10.1007/s10593-014-1420-8

Author Biography

А. К. Ширяев, Samara State Technical University

Андрей Константинович Ширяев

Кафедра органической химии, профессор

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Published

2013-11-08

Issue

No. 11 (2013)

Section

Original Papers