Synthesis of N-[1-benzyloxycarbonyl-2-(<i>R</i>,<i>S</i>)ethoxycarbonyl-4-pyrrolidinyl]alanylproline

Authors

  • М. Ю. Каткевич Latvian Institute of Organic Synthesis, Riga LV-1006
  • Дз. Э. Силе Latvian Institute of Organic Synthesis, Riga LV-1006
  • Э. Х. Корчaгова Latvian Institute of Organic Synthesis, Riga LV-1006
  • В. А. Славинская Latvian Institute of Organic Synthesis, Riga LV-1006
  • Э. Лукевиц Latvian Institute of Organic Synthesis, Riga LV-1006

Abstract

A method has been developed for the synthesis of the angiotensin-converting enzyme inhibitor N-[1-benzyloxycarbonyl-2-(R,S)-ethoxycarbonyl-4-pyrrolidinyl]alanylproline by the condensation of N-benzyloxycarbonyl-4-ketoproline ethyl ester with alanylproline. The intermediate Schiff's base was reduced with NaB(CN)H3. The yield of the corresponding maleate was 5.4%.\

How to Cite
Katkevich, M. Y.; Sile, D. É.; Korchagova, É. K.; Slavinskaya, V. A.; Lukevits, É. Chem. Heterocycl. Compd. 1996, 32, 571. [Khim. Geterotsikl. Soedin. 1996, 666.]

For this article in the English edition, see DOI https://doi.org/10.1007/BF01164787

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Published

1996-05-25

Issue

No. 5 (1996)

Section

Original Papers