5-AMINOIMIDAZOLE CHEMISTRY

Аннотация

Contrary to reports in the early literature, 5-aminoimidаzolеs can be prepared in good yield as crystalline compounds. A study of their chemistry has shown that they behave as either C- or N-nucleaphiles depending upon the nature of the electrophile. These addition
and addition-elimination reactions provide useful new routes to nitrogen heterocycles. An important naturally occuring 5-aminoimidazole, aminoimidazole ribonucleotide (AIR) is a biosynthetic precursor of purines and thiamine. The chemistry of 5-aminoimidazоles is discussed and a synthesis of the aminoimidazole ribonucleoside (AIRs) and its biomimetic transformation to novel purine analogues is presented.

How to Cite
Ramsden, C. A. Chem. Heterocycl. Compd. 1995, 31, 1155. [Khim. Geterotsikl. Soedin. 1995, 1323.]

For this article in the English edition, see DOI https://doi.org/10.1007/BF01185582