SYNTHESIS AND ANTIOXIDANT ACTIVITY OF SOME NEW HETEROCYCLES INCORPORATING PYRAZOLO[3,4-<i>d</i>]PYRIMIDIN-4-ONE MOIETY

Аннотация

2-(4-Oxo-1-phenyl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)acetonitrile was used as the key intermediate for the synthesis of polyfunctionally substituted heterocycles (e. g. pyrazoles, pyridine, tetrazole, thiazoles, thiophenes, and chromene) incorporating pyrazolo[3,4-d]pyrimidin-4-one moiety. Representative compounds of the synthesized series were tested and evaluated as antioxidants. Two of the tested compounds (pyrazole and thiophene derivatives) showed antioxidant activity nearly equal to that of ascorbic acid.

How to Cite
El-Mekabaty, A. Chem. Heterocycl. Compd. 2015, 50, 1698. [Khim. Geterotsikl. Soedin. 2014, 1847.]

For this article in the English edition see DOI 10.1007/s10593-015-1640-6