FORMATION OF MAGNETOLIPOSOMES USING SELF-ASSEMBLING 1,4-DIHYDROPYRIDINE DERIVATIVE AND MAGHEMITE γ-Fe₂O₃ NANOPARTICLES

Аннотация

This work demonstrates studies of ferromagnetic nanoparticle functionalization by a lipid-like compound, cationic pyridine amphiphile derived from 1,4-dihydropyridine, 1,1'-{[3,5-bis(dodecyloxycarbonyl)-4-phenyl-1,4-dihydropyridine-2,6-diyl]dimethanediyl}dipyridinium dibromide, and determination of optimal conditions for the production of magnetoliposomes. The following methodologies, such as sonication, spontaneous swelling, and reverse-phase evaporation, were used for the preparation of liposomes. Ferrofluid containing γ-Fe₂O₃ nanoparticles with a positively charged surface was used for the preparation of magnetoliposomes. The obtained soft matter objects were studied by optical microscopy, transmission electron microscopy, and dynamic light scattering techniques. The optimal conditions for the production of magnetoliposomes were found by spontaneous swelling and reverse-phase evaporation methods using ferrofluid with positively charged γ-Fe₂O₃ nanoparticles and cationic 1,4-dihydropyridine derivative.

How to Cite
Petrichenko, O.; Plotniece, A.; Pajuste, K.; Ose, V.; Cēbers, A. Chem. Heterocycl. Compd. 2015, 51, 672. [Khim. Geterotsikl. Soedin. 2015, 51, 672.]

For this article in the English edition see DOI 10.1007/s10593-015-1755-9