SYNTHESIS AND ANTIMICROBIAL EVALUATION OF NOVEL PYRAZOLE-ANNULATED OXYGEN-CONTAINING MACROCYCLES

Авторы

  • Ashok Dongamanti Department of Chemistry, Osmania University
  • Mohan Gandhi Devulapally Department of Chemistry Osmania University
  • Srinivas Gundu Department of Chemistry Osmania University
  • Vikas Kumar Aamate Department of Chemistry Osmania University
  • Shivakanth Chintalapally Department of Genetics Osmania University

DOI:

https://doi.org/10.1007/3210

Ключевые слова:

macrocycles, pyrazole, Vilsmeier–Haack reagent, antimicrobial activity, dialkylation

Аннотация

An efficient approach to the synthesis of fused pyrazole-annulated macrocycles has been demonstrated. Vilsmeier–Haack reaction of substituted o-hydroxyacetophenones with phenyl hydrazine followed by reduction of the resulting pyrazolyl aldehydes yielded the corresponding alcohols. These precursors upon alkylation with dibromoalkanes gave the target library. The structures of the synthesized pro-ducts were established based on 1H, 13C NMR, IR, and mass spectral data. All the final macrocycles were screened for their antimicrobial activity. Compounds bearing electron-donating groups show promising antimicrobial activity against the tested strains.

Биографии авторов

Ashok Dongamanti, Department of Chemistry, Osmania University

Mohan Gandhi Devulapally, Department of Chemistry Osmania University

Srinivas Gundu, Department of Chemistry Osmania University

Vikas Kumar Aamate, Department of Chemistry Osmania University

Shivakanth Chintalapally, Department of Genetics Osmania University

Опубликован

2016-08-26

Выпуск

Раздел

Оригинальные статьи