FACILE CONSECUTIVE THREE-COMPONENT SYNTHESIS OF 3,5-DISUBSTITUTED ISOXAZOLES

Авторы

  • Christina Görgen Heinrich-Heine-Universität Düsseldorf Institut für Organische Chemie und Makromolekulare Chemie
  • Thomas J. J. Müller Heinrich-Heine-Universität Düsseldorf Institut für Organische Chemie und Makromolekulare Chemie

DOI:

https://doi.org/10.1007/3677

Ключевые слова:

alkynes, azidation, copper-free alkynylation, cyclization, isoxazoles, multicomponent reactions

Аннотация

3,5-Di(hetero)aryl-substituted isoxazoles can be rapidly synthesized in a one-pot fashion by a consecutive three-component alkynylation–cyclization sequence starting from (hetero)aroyl chloride, alkynes, and sodium azide/acetic acid under copper-free palladium catalysis as exemplified by 9 different products.

 

Биографии авторов

Christina Görgen, Heinrich-Heine-Universität Düsseldorf Institut für Organische Chemie und Makromolekulare Chemie

former Ph. D. student

Thomas J. J. Müller, Heinrich-Heine-Universität Düsseldorf Institut für Organische Chemie und Makromolekulare Chemie

Chair of Organic Chemistry, Director of Institute

Загрузки

Опубликован

2017-04-23

Выпуск

Том 53 № 4 (2017): Многокомпонентные реакции в синтезе гетероциклов

Раздел

Оригинальные статьи