THREE-COMPONENT HETERO-DOMINO CYCLIZATION AND COPPER-CATALYZED DOUBLE A<sup>3</sup>-COUPLING REACTION OF ETHANE-1,2-DIAMINES, FORMALDEHYDE, AND ALKYNES TO AFFORD 1,3-DIPROPARGYLIMIDAZOLIDINES

Авторы

  • Lu Sun Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, 130 Meilong Rd., Shanghai 200237
  • Mengying Wu Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, 130 Meilong Rd., Shanghai 200237
  • Xi Huang Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, 130 Meilong Rd., Shanghai 200237
  • Jiayi Wang Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, 130 Meilong Rd., Shanghai 200237
  • Gonghua Song Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, 130 Meilong Rd., Shanghai 200237

DOI:

https://doi.org/10.1007/4365

Ключевые слова:

1, 3-dipropargylimidazolidines, A3-coupling, copper catalysis, cyclization, hetero-domino reaction, three-component reaction

Аннотация

A novel and efficient approach to the synthesis of 1,3-dipropargylimidazolidines via a hetero-domino cyclization and copper-catalyzed double A3-coupling reaction of ethane-1,2-diamines, formaldehyde, and alkynes has been reported. The transformation provides a useful method for the synthesis of imidazolidine derivatives.

Биографии авторов

Lu Sun, Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, 130 Meilong Rd., Shanghai 200237

Shanghai Key Laboratory of Chemical Biology, School of Pharmacy

Jiayi Wang, Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, 130 Meilong Rd., Shanghai 200237

Shanghai Key Laboratory of Chemical Biology, School of Pharmacy

Gonghua Song, Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, 130 Meilong Rd., Shanghai 200237

Shanghai Key Laboratory of Chemical Biology, School of Pharmacy

Загрузки

Опубликован

2018-05-16

Выпуск

Том 54 № 3 (2018): Металлокаталитические синтезы гетероциклов

Раздел

Оригинальные статьи