EFFICIENT COPPER-CATALYZED SYNTHESIS OF 2-ARYLBENZIMIDAZOLE DERIVATIVES BY REACTION OF 1-FLUORO-2-NITROBENZENE WITH BENZAMIDINE HYDROCHLORIDES

Авторы

  • Mohammad Hosein Sayahi Payame Noor University (PNU)
  • Mehdi Khoshneviszadeh Shiraz University of Medical Sciences
  • Mehdi Soheilizad Alborz University of Medical Sciences
  • Seyyed Jafar Saghanezhad ACECR-Production Technology Research Institute
  • Mohammad Mahdavi Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences

DOI:

https://doi.org/10.1007/4391

Ключевые слова:

2-arylbenzimidazoles, benzamidine hydrochloride, 1-fluoro-2-nitrobenzene, copper-catalyzed reactions

Аннотация

A novel and efficient approach to the preparation of 2-arylbenzimidazoles is described. Heating a mixture of 1-fluoro-2-nitrobenzene and benzamidine hydrochlorides in the presence of CuBr and K2CO3 in DMSO afforded 2-arylbenzimidazoles in good to excellent yields. The reaction was initiated by nucleophilic aromatic substitution and further proceeded by intramolecular nucleophilic copper-catalyzed cyclization reaction of benzamidine.

Биографии авторов

Mohammad Hosein Sayahi, Payame Noor University (PNU)

Department of Chemistry

Mehdi Khoshneviszadeh, Shiraz University of Medical Sciences

Medicinal & Natural Products Chemistry Research Center

Mehdi Soheilizad, Alborz University of Medical Sciences

CinnaGen Medical Biotechnology Research Center

Mohammad Mahdavi, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences

Endocrinology and Metabolism Research Center

Загрузки

Опубликован

2018-05-18

Выпуск

Том 54 № 3 (2018): Металлокаталитические синтезы гетероциклов

Раздел

Оригинальные статьи