AN IMPROVED SYNTHESIS OF 4-CHLORO-7<i>H</i>-PYRROLO[2,3-<i>d</i>]PYRIMIDINE

Авторы

  • Yu Luo east china normal university

DOI:

https://doi.org/10.1007/4531

Ключевые слова:

pyrimidine, Janus kinase inhibitor, ozonolysis, synthesis.

Аннотация

An improved seven-step synthesis of 4-chloro-7H-pyrrolo[2,3-d]pyrimidine from dimethyl malonate with 31% overall yield is described. The procedure is operationally simple and practical for the synthesis of the 4-chloro-7H-pyrrolo[2,3-d]pyrimidine building block.

Загрузки

Опубликован

2018-07-25

Выпуск

Том 54 № 6 (2018)

Раздел

Оригинальные статьи