ALIPHATIC CHAIN-CONTAINING MACROCYCLES AS DIAZONAMIDE A ANALOGS

Авторы

  • Viktorija Vitkovska Latvian Institute of Organic Synthesis Aizkraukles 21, LV-1006, Riga
  • Rimants Zogota Latvian Institute of Organic Synthesis, Aizkraukles 21, LV-1006, Riga
  • Toms Kalnins Latvian Institute of Organic Synthesis, Aizkraukles 21, LV-1006, Riga
  • Edgars Suna Latvian Institute of Organic Synthesis, 21 Aizkraukles St., Riga LV-1006, Latvia

DOI:

https://doi.org/10.1007/5534

Ключевые слова:

diazonamide A, anticancer agents, macrocycles, ring-closing metathesis.

Аннотация

Aliphatic alkyl chain-containing 12–14-membered macrocycles have been designed as structural analogs of antimitotic natural product diazonamide A. Macrocycles were synthesized from 5-bromooxazole in 7 to 9 linear steps using Ru-catalyzed ring-closing metathesis as the key transformation. Heat effect of binding to α,β-tubulin tetramer (T4-RB3 complex) has been measured for the synthesized macrocycles by isothermal titration calorimetry method.

Загрузки

Опубликован

2020-05-28

Выпуск

Том 56 № 5 (2020)

Раздел

Оригинальные статьи