SYNTHESIS OF ISOXAZOLYLVINYL KETONES FROM SUBSTITUTED FURANS

Авторы

  • Olga V. Serdyuk Южный федеральный университет
  • Frank Hampel Department of Chemistry and Pharmacy, Institute of Organic Chemistry I, Friedrich-Alexander University of Erlangen-Nürnberg, 10 Nikolaus-Fiebiger-St., Erlangen 91058, Germany
  • Vladimir T. Abaev North Ossetian State University named after K. L. Khetagurov, 43–46 Vatutina St., Vladikavkaz 362025, Russia Department of Chemistry, North Caucasus Federal University, 1a Pushkina St., Stavropol 355009, Russia

DOI:

https://doi.org/10.1007/6003

Ключевые слова:

chalcone, furan, isoxazole, ring opening – ring closure reaction.

Аннотация

A new method for the preparation of isoxazolylvinyl ketones related to potential cytotoxic agents has been developed. In the first step, the reaction of furfuryl ketones with hydroxylamine hydrochloride affords the corresponding oximes. Further, the oxidative ring opening – ring closure reaction of oximes leads to isoxazoles with an α,β-unsaturated carbonyl motif. The developed procedure is metal-free and does not require expensive starting materials.

Биографии авторов

Olga V. Serdyuk, Южный федеральный университет

Кафедра органической химии, доцент, кандидат химических наук

Frank Hampel, Department of Chemistry and Pharmacy, Institute of Organic Chemistry I, Friedrich-Alexander University of Erlangen-Nürnberg, 10 Nikolaus-Fiebiger-St., Erlangen 91058, Germany

Department of Chemistry and Pharmacy

Institute of Organic Chemistry I

Загрузки

Опубликован

2020-11-26

Выпуск

Том 56 № 11 (2020)

Раздел

Оригинальные статьи