1-ARYL-4-(2-OXOALKYLSULFANYL)-2,3(5<i>H</i>)-BENZODIAZEPINES: SYNTHESIS AND THIOPHENE RING ANNULATION TO 1,2-DIAZEPINE CORE

Авторы

  • Natalia M. Bohdan Institute of Organic Chemistry, National Academy of Sciences of Ukraine, 5 Akademika Kukharya St., Kyiv 02094, Ukraine
  • Diana S. Stepanova Institute of Organic Chemistry, National Academy of Sciences of Ukraine, 5 Akademika Kukharya St., Kyiv 02094, Ukraine
  • Serhii Yu. Suikov Institute of Organic Chemistry, National Academy of Sciences of Ukraine, 5 Akademika Kukharya St., Kyiv 02094, Ukraine
  • Vadim Yu. Popov L. M. Litvinenko Institute of Physical-Organic Chemistry and Coal Chemistry, National Academy of Sciences of Ukraine, 50 Kharkivs'ke Road, Kyiv 02155, Ukraine
  • Yuri V. Ishkov I. I. Mechnikov Odesa National University, 2 Dvoryanskaya St., Odesa 65082, Ukraine
  • Serhii L. Bohza Институт органической химии НАН Украины

DOI:

https://doi.org/10.1007/7726

Ключевые слова:

2, 3-benzodiazepine, thione, alkylation, cyclization, NMR analysis, synthesis.

Аннотация

1-Aryl-2-[(1-aryl-5H-2,3-benzodiazepin-4-yl)sulfanyl]ethanones were obtained by the alkylation of 1-aryl-2,3-benzodiazepine-4(3H,5H)thiones with 1-aryl-2-bromoethanones. A reaction for the annulation of the thiophene core to the 1,2-diazepine ring as a result of intramolecular cyclization involving a 4-aroylmethylsulfanyl substituent and C(4)–C(5) bond of diazepine was developed. Derivatives of a new thieno[2,3-d][2,3]benzodiazepine heterocyclic system were synthesized.

Биографии авторов

Natalia M. Bohdan, Institute of Organic Chemistry, National Academy of Sciences of Ukraine, 5 Akademika Kukharya St., Kyiv 02094, Ukraine

Senior Researcher of lab of the condensed heterocyclic compounds

Diana S. Stepanova, Institute of Organic Chemistry, National Academy of Sciences of Ukraine, 5 Akademika Kukharya St., Kyiv 02094, Ukraine

Junior Researcher of lab of the condensed heterocyclic compounds

Serhii Yu. Suikov, Institute of Organic Chemistry, National Academy of Sciences of Ukraine, 5 Akademika Kukharya St., Kyiv 02094, Ukraine

Senior Researcher of DEPARTMENT OF PHYSICOCHEMICAL INVESTIGATIONS

Vadim Yu. Popov, L. M. Litvinenko Institute of Physical-Organic Chemistry and Coal Chemistry, National Academy of Sciences of Ukraine, 50 Kharkivs'ke Road, Kyiv 02155, Ukraine

Junior Researcher of Heterocyclic Chemistry department

Yuri V. Ishkov, I. I. Mechnikov Odesa National University, 2 Dvoryanskaya St., Odesa 65082, Ukraine

Prfessor and Chair of Organc and Bioorganic Chemstry department

Serhii L. Bohza, Институт органической химии НАН Украины

Заведующий лабораторией конденсированных гетероциклических соединений Института органической химии НАН Украины

Профессор органической химии в Донецком национальном университете в Виннице, Украина

Загрузки

Опубликован

2023-08-09

Выпуск

Том 59 № 6/7 (2023): UKRAINIAN IMPACT ON HETEROCYCLIC CHEMISTRY AFTER THE THREE DECADES OF INDEPENDENCE

Раздел

Оригинальные статьи