SYNTHESIS AND TUBERCULOSTATIC ACTIVITY OF METHYL 3-ISONICOTINOYLDITHIOCARBAZATE AND S,S'-DIMETHYL DITHIOCARBONATE ISONICOTINOYLHYDRAZONE, AND THEIR REACTIONS WITH AMINES AND HYDRAZINES

Авторы

  • H. Foks Department of Organic Chemistry Medical University of Gdańsk 80-416 Gdańsk
  • J. Mieczkowska Department of Organic Chemistry Medical University of Gdańsk 80-416 Gdańsk
  • M. Janowiec Department of Microbiology, Institute of Tuberculosis Pulmonary Diseases 01-138 Warszawa
  • Z. Zwolska Department of Microbiology, Institute of Tuberculosis Pulmonary Diseases 01-138 Warszawa
  • Z. Andrzejczyk Department of Microbiology, Institute of Tuberculosis Pulmonary Diseases 01-138 Warszawa

Ключевые слова:

1,3-diazacycloalkanes, 1,2-diaziridine, S,S'-dimethyl dithiocarbonates, 1,3-dithiolane, isonicotinhydrazide, S-methyl dithiocarbazates, 1,2,4-triazoles, tuberculostatic activity

Аннотация

Methyl 3-isonicotinoyldithiocarbazates and S,S'-dimethyl dithiocarbonate isonicotinoylhydrazone were prepared. Their reactions with primary and secondary amines, diamines, and hydrazines were studied. The newly obtained derivatives did not show tuberculostatic activity in vitro.

How to Cite
Foks, H.; Mieczkowska, J.; Janowiec, M.; Zwolska, Z.; Andrzejczyk, Z. Chem. Heterocycl. Compd. 2002, 38, 810. [Khim. Geterotsikl. Soedin. 2002, 918.]

For this article in the English edition, see DOI https://doi.org/10.1023/A:1020681604052

Загрузки

Опубликован

2002-07-25

Выпуск

№ 7 (2002)

Раздел

Оригинальные статьи