A FACILE PROTOCOL FOR THE DIRECT ARYLATION OF THIAZOLES UNDER COMBINED MICROWAVE AND ULTRASOUND IRRADIATION

Авторы

  • Yanqiu Zhang Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237
  • Zhiliang Zhang Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237
  • Jiayi Wang Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237
  • Yanqing Peng Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237
  • Gonghua Song Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237

Ключевые слова:

Direct arylation, Thiazole, Microwave, Ultrasound, Thiazole N-oxide

Аннотация

A versatile and efficient protocol has been developed for the direct arylation of thiazoles at positions 2 and 5 and thiazole N-oxides at positions 2, 4, and 5. This method utilizes combined microwave and ultrasound irradiation with water as the reaction solvent. The approach enabled the synthesis of various 2,5-diarylthiazoles in moderate to high yields. Furthermore, the protocol allowed to successfully prepare 2-(3,5-dimethylphenyl)-5-methyl-4-phenylthiazole, a representative 2,4,5-trisubstituted thiazoles with different substituents. This approach not only simplifies the process but also reduces costs and minimizes environmental impact, making it a sustainable alternative.

Опубликован

2026-05-15

Выпуск

Том 61 № 11/12 (2025)

Раздел

Оригинальные статьи