SYNTHESIS OF CHIRAL PYRROLIDINE DERIVATIVES WITH PROMISING PHARMACOLOGICAL ACTIVITY

Abstract

Enantiomerically pure pyrrolidine derivatives, incorporating a pharmacologically relevant asymmetric center and diverse substituents, were synthesized from (S)-proline. Comprehensive characterization (NMR, HRMS, FTIR, ECD, X-ray) and in silico ADMET (SwissADME) analysis revealed favorable physicochemical properties and drug-likeness for the majority of the compounds. Key structural modifications significantly impacted lipophilicity and solubility. Molecular docking studies revealed promising binding affinities toward a specific target (Ras:SOS complex), highlighting the compounds' potential for drug development. Further biological evaluation is necessary to fully assess their pharmacological activity.