SYNTHESIS OF HETEROCYCLES ON THE BASIS OF PRODUCTS OF ARYLATION OF UNSATURATED COMPOUNDS. 22. 3-ARYL-2-CHLOROPROPANAL IN THE SYNTHESIS OF N-ARYL-5-(R-BENZYL)-1,3-THIAZOLE-2-AMINES

Authors

  • В. С. Матийчук Ivan Franko Lviv National University
  • Н. Д. Обушак Ivan Franko Lviv National University
  • Н. И. Пидлыпный Ivan Franko Lviv National University
  • Ю. В. Остапюк Ivan Franko Lviv National University
  • Р. М. Волощук Ivan Franko Lviv National University

DOI:

https://doi.org/10.1007/2955

Keywords:

2-aminothiazoles, arylthioureas, derivatives of thiazole, α-chloro aldehydes, arylation, the Meerwein reaction

Abstract

3-Aryl-2-chloropropanal was obtained by the reaction of arenediazonium chlorides with acrolein in the presence of copper(II) chloride. N-Aryl(2-pyridyl)-5-(R-benzyl)-1,3-thiazole-2-amines were formed in high yield by the reaction of these aldehydes with aryl- and 2-pyridylthioureas. The same compounds were obtained by the reaction of 5-(R-benzyl)-1,3-thiazole-2-amines with aniline.

How to Cite
Matiychuk, V. S.; Obushak, N. D.; Pidlypnyi, N. I.; Ostapiuk, Yu. V.; Voloshchuk, R. M. Chem. Heterocycl. Compd. 2010, 46, 495. [Khim. Geterotsikl. Soedin. 2010, 624.]

For this article in the English edition see DOI 10.1007/s10593-010-0537-7

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Published

2016-01-13

Issue

No. 4 (2010)

Section

Original Papers