PYRAZOLES, ISOXAZOLES, AND 1,2,3-TRIAZOLES AS ANALOGS OF THE NATURAL CYTOSTATIC COMBRETASTATIN A-4: EFFICIENT ROUTES OF SYNTHESIS, TUBULIN INHIBITION, AND CYTOTOXICITY

Authors

  • Роман К. Костин I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), 8, Build. 2 Trubetskaya St., Moscow 119991, Russia
  • Александр С. Маршавин Lomonosov Moscow State University, 1, Build. 3 Leninskie Gory, Moscow 119991, Russia

DOI:

https://doi.org/10.1007/6370

Keywords:

combretastatin A-4, combretastatin analogs, 3, 5-diarylisoxazole, heterocycles, pyrazole, pyrazoline, 1, 2, 3-triazole, tubulin, cytotoxicity, tubulin-binding agents.

Abstract

The review discusses the advantages and disadvantages of combretastatin A-4, presents the most effective methods for the synthesis of its 1,2,3-triazole, pyrazole, isoxazole analogs. The structural formulas of the analogs of combretastatin A-4 which are the most active against cancer cells, together with indicators of cytotoxicity, are also presented.

 

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Published

2021-11-26

Issue

Vol. 57 No. 11 (2021)

Section

Review Articles