METHOD OF THE SYNTHESIS OF SELENIUM HOMOLOG OF RUCAPARIB

Authors

  • Sindija Lapcinska Latvian Institute of Organic Synthesis, 21 Aizkraukles St., Riga LV-1006, Latvia
  • Pavel Arsenyan Latvian Institute of Organic Synthesis, 21 Aizkraukles St., Riga LV-1006, Latvia

DOI:

https://doi.org/10.1007/7487

Keywords:

rucaparib, selenium, electrophile, 5-endo-dig, one-pot synthesis.

Abstract

We have developed a practical protocol from readily available 5-fluoro-2-hydroxybenzoic acid to access a selenium homolog of rucaparib. The crucial step is Lewis acid mediated 5-endo-dig cyclization of ethynyl aniline with the following intramolecular electrophilic selenylation leading to the one-pot construction of a tricyclic system.

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Published

2023-05-31

Issue

Vol. 59 No. 4/5 (2023)

Section

Original Papers