METHOD OF THE SYNTHESIS OF SELENIUM HOMOLOG OF RUCAPARIB

Авторы

  • Sindija Lapcinska Latvijas Organiskās sintēzes institūts
  • Pavel Arsenyan Latvian Institute of Organic Synthesis, 21 Aizkraukles St., Riga LV-1006, Latvia

DOI:

https://doi.org/10.1007/7487

Ключевые слова:

rucaparib, selenium, electrophile, 5-endo-dig, one-pot synthesis.

Аннотация

We have developed a practical protocol from readily available 5-fluoro-2-hydroxybenzoic acid to access a selenium homolog of rucaparib. The crucial step is Lewis acid mediated 5-endo-dig cyclization of ethynyl aniline with the following intramolecular electrophilic selenylation leading to the one-pot construction of a tricyclic system.

Загрузки

Опубликован

2023-05-31

Выпуск

Том 59 № 4/5 (2023)

Раздел

Оригинальные статьи