SYNTHESIS OF ISOXAZOLINYLXANTHINES

Authors

  • В. Дирненс Latvian Institute of Organic Synthesis, Riga LV-1006
  • И. Скрастиня Latvian Institute of Organic Synthesis, Riga LV-1006
  • Ю. Попелис Latvian Institute of Organic Synthesis, Riga LV-1006
  • Э. Лукевиц Latvian Institute of Organic Synthesis, Riga LV-1006

DOI:

https://doi.org/10.1007/7676

Keywords:

allyltheobromine, allyltheophylline, arylnitrile oxides, isoxazoline

Abstract

1-[5-(3-Arylisoxazolin-2-yl)methyl]-3,7-dimethylxanthines  have been synthesized by the [2+3] cycloaddition  of arylnitrile oxides to allyltheobromine. 7-{5-[3-(2,4-Dichlorophenyl)isoxazolin-2-yl]methyl}-1,3-dimethylxanthine was obtained by  the addition of 2,4-dichlorobenzonitrile oxide to allyltheobromine.  The  addition of arylnitrile oxides  to structural isomers of methylxanthines proceeds regioselectively with the formation of 3,5-disubstituted isoxazolines. 

How to Cite
Dirnens, V.; Skrastina, I.; Popelis, J.; Lukevics, E.  Chem. Heterocycl. Compd. 2007, 43, 193. [Khim. Geterotsikl. Soedin. 2007, 245.]

For this article in the English edition see DOI 10.1007/s10593-007-0031-z


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Published

2023-04-03

Issue

No. 2 (2007)

Section

Original Papers