INVESTIGATIONS ON 2,3'-BIQUINOLINE. 17. REGIOSELECTIVITY OF THE HALOGENATION OF 2,3'-BIQUINOLINE DERIVATIVES

Authors

  • Н. В. Демидова Stavropol State University, Stavropol 355009
  • Н. Ц. Караиванов Stavropol State University, Stavropol 355009
  • В. И. Гончаров Stavropol State Medical Academy, Stavropol 355017
  • А. В. Аксенов Stavropol State University, Stavropol 355009

DOI:

https://doi.org/10.1007/8194

Keywords:

1'-alkyl-1', 2'-dihydro-2, 3'-biquinolin-2'-ones, 4'-dihydro-2, 3'-biquinolin-4'-ones, 2, 3'-biquinoline, bromination, chlorination, electrophilic substitution

Abstract

A method has been developed for the synthesis of bromo and chloro derivatives of 2,3'-biquinoline and 2,3'-biquinolones based on the bromination and chlorination in various media. It was found that the bromination of 2,3'-biquinoline in strongly acidic medium occurred on the 2-quinoline fragment and in weak acid on the 3-quinoline and that it takes place via a stage of formation of a dihydro derivative. 1'-Alkyl-1',4'-dihydro-2,3'-biquinolin-4'-ones and 1'-alkyl-1',2'-dihydro-2,3'-biquinolin-2'-ones are halogenated at position 6'.

How to Cite
Demidova, N. V.; Karaivanov, N. Ts.; Goncharov, V. I.; Aksenov, A. V.  Chem. Heterocycl. Compd. 2005, 41, 1167. [Khim. Geterotsikl. Soedin. 2005, 1372.]

For this article in the English edition, see DOI 10.1007/s10593-005-0297-y


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Published

2023-10-25

Issue

No. 9 (2005)

Section

Original Papers