REACTIONS OF 2,3-DIOXOPYRROLO[2,1-<i>a</i>]ISOQUINOLINES WITH ACTIVE N-NUCLEOPHILES

Authors

  • Н. Н. Полыгалова Perm State Pharmaceutical Academy, Perm 614990
  • А. Г. Михайловский Perm State Pharmaceutical Academy, Perm 614990

DOI:

https://doi.org/10.1007/8196

Keywords:

aliphatic diamines, bisenaminoketoamides, hydrazides of aromatic acids, hydrazine, hydroxamic acids, hydroxylamine, 5, 5-dialkyl-2, 3-dioxopyrrolo[2, 1-a]isoquinolines, perhydropyridazine, thiosemicarbazide

Abstract

It is shown that 2,3-dioxopyrrolo[2,1-a]isoquinolines react readily with aliphatic diamines and hydroxyamine with opening of the dioxopyrrole ring and formation of the corresponding bisenaminoketoamides and hydroxamic acids. Reaction with the thiosemicarbazide and hydrazides of aromatic acids proceeds without opening of the pyrrole ring at the ketone carbonyl. Derivatives of hexahydropyridazine are formed when compounds with carboxyethyl groups at position 1 react with hydrazine.

How to Cite
Polygalova, N. N.; Mikhailovskii, A. G.  Chem. Heterocycl. Compd. 2005, 41, 1178. [Khim. Geterotsikl. Soedin. 2005, 1383.]

For this article in the English edition, see DOI 10.1007/s10593-005-0299-9

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Published

2023-10-25

Issue

No. 9 (2005)

Section

Original Papers