SYNTHESIS OF SUBSTITUTED AND CONDENSED TETRAHYDROSPIRO[BENZO-2-AZEPINECYCLOHEXANES] FROM 1-CYANO- AND 1-CARBAMOYL-5-METHYL-4,5-DIHYDRO-3H-SPIRO[BENZO-2-AZEPINE-3,1'-CYCLOHEXANES]

Authors

  • А. В. Варламов Russian People's Friendship University, Moscow 117198
  • Д. Г. Грудинин Russian People's Friendship University, Moscow 117198
  • А. А. Еганов Russian People's Friendship University, Moscow 117198
  • А. И. Чернышев Russian People's Friendship University, Moscow 117198
  • А. Н. Левов Russian People's Friendship University, Moscow 117198

DOI:

https://doi.org/10.1007/8245

Keywords:

diaziridinobenzo-2-azepinecyclohexane spirobenzo-2-azepinecyclohexanes triazolobenzo-2-azepinecyclohexanes

Abstract

Substitution of the nitrile group by hydroxylamine and hydrazine has been effected in 1-cyanodihydrospiro[benzo-2-azepine-3,1'-cyclohexane]. From the 1-cyano and 1-hydrazino derivatives tetrahydrospiro{1,2,3- and 1,2,4-triazolo[5,1-a]benzoazepine-5,1'-cyclohexanes} have been obtained. It was established that 1-carbamoyldihydrospiro[benzo-2-azepine-3,1'-cyclohexanes] are converted under the conditions of the Hoffmann reaction into spiro{diaziridino[3,1-a]benzo-2-azepine-3,1'-cyclohexane}, and is reduced by sodium borohydride to the tetrahydro derivative.

How to Cite
Varlamov, A. V.; Grudinin, D. G.; Eganov, A. A.; Chernyshev, A. I.; Levov, A. N.  Chem. Heterocycl. Compd. 2005, 41, 872. [Khim. Geterotsikl. Soedin. 2005, 1033.]

For this article in the English edition, see DOI 10.1007/s10593-005-0241-1


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Published

2023-10-31

Issue

No. 7 (2005)

Section

Original Papers