THE SILYL METHOD FOR THE SYNTHESIS OF 1[-2(PHENOXY)ETHYL]URACILS

Authors

  • М. С. Новиков Pharmacological Research Institute, Volgograd State Medicinal University, Volgograd 400131
  • А. А. Озеров Pharmacological Research Institute, Volgograd State Medicinal University, Volgograd 400131

DOI:

https://doi.org/10.1007/8255

Keywords:

2, 4-bis(trimethylsiloxy)pyrimidine, 1-bromo-2-(phenoxy)ethane, N(1)-alkylation, the Gilbert–Johnson reaction

Abstract

A modification of the method for the synthesis of N(1)-substituted derivatives of uracil is proposed using the Gilbert–Johnson reaction, which consists of the alkylation of 5-substituted 2,4-bis(trimethylsiloxy)pyrimidines with 1-bromo-2-(phenoxy)ethanes of low reactivity at 180-185° without solvent. The corresponding 1-[2-(phenoxy)ethyl]uracils, which were obtained in 55-74% yield, contained no impurities of the N(1),N(3)-disubstituted compounds.

How to Cite
Novikov, M. S.; Ozerov, A. A.  Chem. Heterocycl. Compd. 2005, 41, 905. [Khim. Geterotsikl. Soedin. 2005, 1071.]

For this article in the English edition, see DOI 10.1007/s10593-005-0246-9

 

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Published

2023-11-01

Issue

No. 7 (2005)

Section

Original Papers