A NEW FACILE METHOD FOR THE SYNTHESIS OF 3-IMIDAZOLYLPROPIONIC ACID <i>N</i>-OXIDES

Авторы

  • Anton V. Kutasevich РХТУ им Д.И. Менделеева
  • Valery P. Perevalov D. Mendeleyev University of Chemical Technology of Russia
  • Vitaly S. Mityanov D. Mendeleyev University of Chemical Technology of Russia
  • Boris V. Lichitsky N.D. Zelinsky Institute of Organic Chemistry
  • Andrey N. Komogortsev N.D. Zelinsky Institute of Organic Chemistry
  • Mikhail M. Krayushkin N.D. Zelinsky Institute of Organic Chemistry
  • Tatyana Yu. Koldaeva D. Mendeleyev University of Chemical Technology of Russia
  • Vladimir S. Miroshnikov D. Mendeleyev University of Chemical Technology of Russia

DOI:

https://doi.org/10.1007/4905

Ключевые слова:

CH acids, imidazole N-oxides, Meldrum's acid, CH functionalization, multicomponent reaction.

Аннотация

A facile and efficient method for the preparation of 3-imidazolylpropionic acid N-oxides has been developed. It involves condensation of 2-unsubstituted imidazole N-oxide with an aldehyde and Meldrum's acid followed by hydrolysis and decarboxylation of the corresponding adduct. This method tolerates a broad variation in the structure of starting aldehydes as well as N-oxides.

Загрузки

Опубликован

2019-03-12

Выпуск

Том 55 № 2 (2019)

Раздел

Оригинальные статьи